Call for Papers and Posters
Computational Approaches to Drug Repurposing and Pharmacology
Pacific Symposium on Biocomputing
Meanwhile, there is an ever-growing effort to apply computational power to improve the effectiveness and efficiency of drug discovery. Traditional computational methods in drug discovery were focused on understanding which proteins could make good drug targets, the modeling drugs binding to proteins, and the analysis of basic biological data. With the emergence of systems biology and translational research in recent years, a new set of computational methods are being developed which examine drug-target associations and drug off-target effects through system and network approaches. These new approaches take advantage of the unprecedented large-scale high-throughput measurements, such as drug chemical structures, transcriptional responses after drug treatment, knowledge from the literature, and public repositories for these data and knowledge. As a result, computational scientists can now gain evidence for reusing an existing drug for a different use or generate testable hypotheses for further screening.
Despite the progress, there is clearly room for technical improvement with regard to repurposing approaches. As stated in a recent journal, the editors "expect methods to continue evolve rapidly with possibly only a limited number of approaches becoming mainstream." Furthermore, to materialize the true potential and impact of these methods, much work is needed to show that they can be successfully adopted into practical applications. Our objective in this session is to bring together computational biologists, drug-discovery scientists, and translational investigators, from industry, academia, and government, to showcase the latest methodologies and findings in computational drug repositioning.
Stanford University School of Medicine
|S. Joshua Swamidass
Washington University School of Medicine
All deadlines are at midnight Pacific Standard Time.
The file formats we accept are: postscript (*.ps) and Adobe Acrobat (*.pdf)). Attached files should be named with the last name of the first author (e.g. altman.ps or altman.pdf). Hardcopy submissions or unprocessed TeX or LaTeX files will be rejected without review.
Each paper must be accompanied by a cover letter. The cover letter must state the following:
Submitted papers are limited to twelve (12) pages in our publication format. Please format your paper according to instructions found at http://psb.stanford.edu/psb-online/psb-submit/. If figures cannot be easily resized and placed precisely in the text, then it should be clear that with appropriate modifications, the total manuscript length would be within the page limit.
Contact PSB for additional information about paper submission requirements.