Co-chairs:
Contact: Quaid Morris (quaid.morris@gmail.com)
Schedule
Background and
Scope
Regulation
of gene expression at the post-transcriptional level is widespread in
eukaryotes. As in the case of transcriptional regulation, differential
regulation of gene expression at the levels of mRNA splicing, stability and
localization is known to control networks of functionally-related genes.
The goal
of our 3 hour workshop is to introduce some recent work in the area of
post-transcriptional regulation to a wider computational community, discuss
some of the unique computational problems faced in this area, and to present
some preliminary solutions to these problems.
In
particular, we will focus on emerging computational and large-scale
experimental strategies (e.g. microarray and deep
sequencing) for investigating aspects of gene regulation at the
post-transcriptional level, with an emphasis on the identification and
characterization of the cis- and trans-acting RNA and
protein components involved. We will
also be exploring new developments in computational methods to detect and
characterize cis-regulatory signals encoded in mRNAs.
Some proposed
topics:
·
Alternative
splicing
- Identifying
and quantifying alternative splicing events using microarrays
and deep sequencing (i.e. mRNA-Seq).
- Alternative
splicing networks and the splicing code.
- Associating
SNPs and other sources of genetic variation with
changes in splicing
·
RNA-protein
interactions
- Motif
models for RNA-binding proteins (RBP) and algorithms for fitting those models
to data.
·
Evolutionary
models
- Models
of the evolution of PTR mechanisms
-
Detecting conservation and change of RNA-binding protein sites
-
Evolutionary models of miRNA target site or RBP
target site accessibility.
·
Regulatory
Networks
- Methods
for inferring networks of post-transcriptional regulation, or networks that combine
both transcriptional and post-transcriptional regulatory networks.
·
MicroRNAs
- Methods
for predicting microRNA targets based on sequence,
expression, and/or secondary structure
Call for Abstracts
Our
workshop will include talks selected from submitted abstracts as well as talks from
invited speakers. We also encourage
abstract submissions from those wishing to present a poster. Submitted abstracts will not be published in
the PubMed-indexed
Submission instructions
Please submit your abstracts
in Word, RTF, PDF, or Postscript format to ptr.session.psb09@gmail.com.
The co-chairs will determine
which abstracts will be invited for oral presentations.
If your abstract is selected
for an oral or poster presentation, you will be given an opportunity to submit
a revised version of your abstract in early November.
Please also note if you are
invited to speak at our workshop or wish to present a poster, you must register
for
Important Dates
Abstract
submission deadline:
Notification
of abstract decisions:
Deadline
for speaker registration:
Meeting: