Post-Transcriptional Gene Regulation: RNA-Protein Interactions, RNA Processing, mRNA Stability and Localization
Benjamin Blencowe1,2, Steven Brenner3, Timothy Hughes1,2, and Quaid Morris1,2,4
1Department of Molecular Genetics, University of Toronto, 1 King's College Rd., Toronto, ON, M5S 1A8, Canada; 2Banting and Best Department of Medical Research, University of Toronto, 160 College Street, Toronto, ON, M5G 1L6, Canada; 3Departments of Molecular and Cell Biology and Plant and Microbial Biology, University of California, Berkeley, California 94720, USA; 4Department of Computer Science, University of Toronto, 10 King’s College Road, Toronto, ON, M5S 3G4, Canada
Pacific Symposium on Biocomputing 14:545-548(2009)
Abstract
The goal of our workshop is to introduce some recent work in the area of post- transcriptional regulation to a wider computational community, discuss some of the unique computational problems faced in this area, and to present some preliminary solutions to these problems. In particular, we will focus on emerging computational and large-scale experimental strategies (e.g. microarray and deep sequencing) for investigating aspects of gene regulation at the post-transcriptional level, with an emphasis on the identification and characterization of the cis- and trans-acting RNA and protein components involved. We will also be exploring new developments in computational methods to detect and characterize cis-regulatory signals encoded in mRNAs.
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