Drug Intervention Response Predictions with Paradigm (DIRPP) Identifies Drug Resistant Cancer Cell Lines and Pathway Mechanisms of Resistance
Douglas Brubaker, Analisa Difeo, Yanwen Chen, Taylor Pearl, Kaide Zhai, Gurkan Bebek, Mark Chance, Jill Barnholtz-Sloan
1Case Center for Proteomics and Bioinformatics, 2Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 3Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, 4 Massachusetts Institute of Technology
Email: dkb50@case.edu
Pacific Symposium on Biocomputing 19:125-135(2014)
Abstract
We present a novel pipeline called DIRPP, Drug Intervention Response Predictions with PARADIGM7 , which predicts a cell line’s response to a drug intervention from molecular data. PARADIGM (Pathway Recognition Algorithm using Data Integration on Genomic Models) is a probabilistic graphical model used to infer patient specific genetic activity by integrating copy number and gene expression data into a factor graph model of a cellular network.
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