Utilization of an EMR-Biorepository to Identify the Genetic Predictors of Calcineurin-Inhibitor Toxicity in Heart Transplant Recipients
Matthew Oetjens, William S. Bush, Kelly A. Birdwell, Holli H. Dilks, Erica A. Bowton, Joshua C. Denny, Russell A. Wilke, Dan M. Roden, Dana C. Crawford
1Center for Human Genetics Research, 2Department of Biomedical Informatics, Center for Human Genetics Research, 3Department of Medicine, 4Vanderbilt Technologies for Advanced Genomics Core Facility, 5Office of Personalized Medicine, 6Department of Biomedical Informatics
Email: matthew.t.oetjens@vanderbilt.edu, william.s.bush@vanderbilt.edu, kelly.birdwell@vanderbilt.edu, holli.dilks@chgr.mc.vanderbilt.edu, erica.a.bowton@vanderbilt.edu, josh.denny@vanderbilt.edu
Pacific Symposium on Biocomputing 19:253-264(2014)
Abstract
In this study we utilized BioVU, Vanderbilt University Medical Center’s DNA biorepository linked to de-identified electronic medical records to identify a cohort of 115 heart transplant recipients prescribed calcineurin-inhibitors to identify genetic risk factors for CNIT We identified 37 cases of nephrotoxicity in our cohort, defining nephrotoxicity as a monthly median estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m2 at least six months post-transplant for at least three consecutive months.
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