PSB - Abstract

The Stream Algorithm: Computationally Efficient Ridge-Regression via Bayesian Model Averaging, and Applications to Pharmacogenomic Prediction of Cancer Cell Line Sensitivity

Elias Chaibub Neto¹, In Sock Jang², Stephen H. Friend³, Adam A. Margolin⁴

Sage Bionetworks
Email: elias.chaibub.neto@sagebase.org¹, in.sock.jang@sagebase.org², friend@sagebase.org³, margolin@sagebase.org⁴

Pacific Symposium on Biocomputing 19:27-38(2014)

Abstract

Toshow in simulation studies and in the analysis of two large cancer cell line data panels that our algorithm achieves slightly better predictive performance than cross-validated ridge-regression while requiring only a fraction of the computation time.

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