Tools for assembling the cell: Towards the era of cell structural bioinformatics.

Hu M(1), Zhang X, Latham A, Šali A, Ideker T, Lundberg E.

Author information:
(1)Department of Medicine, University of California San Diego, San Diego, CA,
USA†These authors contributed equally.

Pac Symp Biocomput. 2024;29:661-665

© 2024 World Scientific
Open Access chapter published by World Scientific Publishing Company and distributed under the terms of the Creative Commons Attribution (CC BY) 4.0 License.

Abstract

Cells consist of large components, such as organelles, that recursively factor into smaller systems, such as condensates and protein complexes, forming a dynamic multi-scale structure of the cell. Recent technological innovations have paved the way for systematic interrogation of subcellular structures, yielding unprecedented insights into their roles and interactions. In this workshop, we discuss progress, challenges, and collaboration to marshal various computational approaches toward assembling an integrated structural map of the human cell.