Contact: Quaid Morris (email@example.com)
Background and Scope
Regulation of gene expression at the post-transcriptional level is widespread in eukaryotes. As in the case of transcriptional regulation, differential regulation of gene expression at the levels of mRNA splicing, stability and localization is known to control networks of functionally-related genes.
The goal of our 3 hour workshop is to introduce some recent work in the area of post-transcriptional regulation to a wider computational community, discuss some of the unique computational problems faced in this area, and to present some preliminary solutions to these problems.
In particular, we will focus on emerging computational and large-scale experimental strategies (e.g. microarray and deep sequencing) for investigating aspects of gene regulation at the post-transcriptional level, with an emphasis on the identification and characterization of the cis- and trans-acting RNA and protein components involved. We will also be exploring new developments in computational methods to detect and characterize cis-regulatory signals encoded in mRNAs.
Some proposed topics:
· Alternative splicing
- Identifying and quantifying alternative splicing events using microarrays and deep sequencing (i.e. mRNA-Seq).
- Alternative splicing networks and the splicing code.
- Associating SNPs and other sources of genetic variation with changes in splicing
· RNA-protein interactions
- Motif models for RNA-binding proteins (RBP) and algorithms for fitting those models to data.
· Evolutionary models
- Models of the evolution of PTR mechanisms
- Detecting conservation and change of RNA-binding protein sites
- Evolutionary models of miRNA target site or RBP target site accessibility.
· Regulatory Networks
- Methods for inferring networks of post-transcriptional regulation, or networks that combine both transcriptional and post-transcriptional regulatory networks.
- Methods for predicting microRNA targets based on sequence, expression, and/or secondary structure
Call for Abstracts
workshop will include talks selected from submitted abstracts as well as talks from
invited speakers. We also encourage
abstract submissions from those wishing to present a poster. Submitted abstracts will not be published in
Please submit your abstracts in Word, RTF, PDF, or Postscript format to firstname.lastname@example.org.
The co-chairs will determine which abstracts will be invited for oral presentations.
If your abstract is selected for an oral or poster presentation, you will be given an opportunity to submit a revised version of your abstract in early November.
Please also note if you are
invited to speak at our workshop or wish to present a poster, you must register
Abstract submission deadline:
Notification of abstract decisions:
for speaker registration: