Overcoming health disparities in precision medicine

A session of the Pacific Symposium of Bioinformatics

Big Island of Hawaii, January 3-7, 2023

Precision medicine and precision public health rely on the premise that determinants of disease incidence and differences in response to interventions can be identified and their biology well enough understood that applications to reduce risk of disease and improve treatment can be developed. However, there are well-documented racial and ethnic disparities throughout health care at the patient, provider, and health care system levels. These disparities are driven by a complex interplay among social, psychosocial, lifestyle, environmental, health system, and biological determinants of health. As the minority populations within the United States grow to record numbers, and precision medicine is beginning to be deployed worldwide, it is increasingly important to invest in efforts to characterize, understand, and end racial and ethnic disparities in health care. New computational and statistical methods are needed to assess, counteract, and overcome health disparities in healthcare. This session of the Pacific Symposium on Biocomputing aims to highlight new analyses, methods, algorithms or datasets that can be applied across the continuum from research to translation to overcome disparities in precision medicine.

Health equity

Session Topics

Topics within the scope of this session include:

Genomic research and its translation
  • Methods for trans-ancestry GWAS
  • Leveraging genetic variation across world populations
  • Assessment of variant pathogenicity across ancestries
  • Disentangling genetic ancestry vs social determinants of health in genomic research
Disease risk and outcome predictions
  • Portability of polygenic risk scores (PRS)
  • Methods for selection of portable PRS
  • Adjustment of PRS across populations
  • Incorporation of clinical factors avoiding embedded bias
Precision Oncology and Clinical Trials
  • Impact of ancestry in cancer incidence and outcomes
  • Ancestry correlates somatic mutation landcapes
  • Ancestry impact on cancer transcriptional patterns
  • Measuring and increasing diversity in clinical trails
  • Ancestry correlates of drug responses and adverse events
  • Impact of racial differences on drug response on inequities
  • Methods to achieve "Pharmacoequity"
  • Fairness in artificial intelligence applied in medicine
  • Identifying and reducing racial biases in AI models
  • Assessing for diversity in training data
  • Monitoring for model drift due to racial biases
  • Resources for clinical research and medicine
  • Development of diverse biobanks and EHR resources
  • Characterizing patients via genetics instead of race
  • Assessment of inequities across the precision medicine continuum
  • Session Organizers

    Submission Information

    Important dates

    Paper Submission Deadline: August 1, 2022
    Notification of Acceptance: September 9, 2022
    Poster/Abstract Submission Deadline: December 5, 2022
    Conference Date: January 3 - 7, 2023

    Proceeding papers

    The core of the conference consists of rigorously peer-reviewed full-length papers reporting on original work. All accepted papers will be published electronically and indexed in PubMed, and the best of these will be presented orally to the entire conference. PSB will also initiate submission to PubMed Central (PMC); however, PMC indexing applies only to papers that comply with the NIH Public Access Policy. Submitted papers are limited to twelve (12) pages (not including the cover letter) in the PSB publication format. Papers must be submitted to the PSB paper management system. For details see the Pacific Symposium of Biocomputing website.

    Each paper must be accompanied by a cover letter. The cover letter should be the first page of your paper submission. The cover letter must state the following:

    • The email address of the corresponding author
    • Indicate that your submission is directed to the "Overcoming Health Disparities" session
    • The submitted paper contains original, unpublished results, and is not currently under consideration elsewhere
    • All co-authors concur with the contents of the paper

    Please note that the submitted papers are reviewed and accepted on a competitive basis. At least three reviewers will be assigned to each submitted manuscript.


    Researchers wishing to present their research without official publication are encouraged to submit a one page abstract by the abstract deadline listed above to present their work in the poster session.

    Conference Venue

    The session will be held as part of the Pacific Symposium on Biocomputing, at the Fairmont Orchid Resort in the Big Island of Hawaii