Certain regions within proteins and some entire proteins are not ordered into unique structure, but rather exist as ensembles of structures. There is a growing awareness that these 'disordered' or 'unfolded' proteins often carry out important biological functions.
Disordered regions of sequence in some cases function to mechanically uncouple structured domains making their dyanmics less constrained: such linkers are important in a diverse collection of proteins, from viral attachment proteins to transcription factors. Disordered regions provide access for protease digestion: such directed digestion is apparently critical for the regulation of many important cellular processes.
Disorder-to-order transitions may be one of the major factors in biomechanics,
for example in the development of force by protein assemblies. Finally,
disordered regions are clearly involved in molecular recognition via disorder-to-order
transitions: numerous examples of disorder-to-order upon complex formation
are by now well-characterized, and biological advantages for this type
of molecular recognition have been proposed.
Purpose of the Session
We hope to bring together an array of researchers who focus on different aspects of disordered or unfolded sequences. Although the Pacific Symposium on Biocomputing (PSB) has an overall computational emphasis, experimentalists and theorists are strongly encouraged to participate in the various scientific sessions.
Areas of Interest
If you are working on, or interested in, any aspect of disordered or unfolded sequences, we would like to invite you to participate in our session. Specifically, we seek manuscript submissions on the characterization and investigation of disordered or unfolded sequences using any approach whatsoever, but especially involving the following categories:
Please respond to any of the co-chairs of this session by e-mail as
soon as possible if you would like to participate in Disorder in Protein
Structure and Function.
A. Keith Dunker -
Department of Biochemistry,
Washington State University,
Pullman, WA 99164-4660
Agouron Pharmaceuticals, Inc.
3565 General Atomics Court
San Diego, CA 92121
Department of Chemistry