We would like to invite contributions with relevance to improving statistical and computational methodology in precision and personalized medicine that describe either (1) a new problem including ideas on how to tackle them, (2) a methodological improvement over solutions to existing problems alongside empirical evaluation, (3) adaptations of existing solutions to datasets with real-world scale. We encourage submissions that span the full range from genotype to intermediate phenotype/physiology to disease phenotype/physiology. The focus will be on methods applicable to large, real-world problems. Both frequentist and Bayesian perspectives will be welcome.

Examples of topics and problems within the scope of this session include :

• Novel statistical and computational approaches for genome sequence analysis of omics data, such as DNA, RNA and bisulfite sequencing.
• Methodology for making use of rare and low frequency variants arising from whole-genome and exome sequencing: combining information across individuals or within a locus, prioritisation of mutations.
• Gene expression studies: modeling hidden factors, characterizing cell types in heterogeneous tissues, removing confounding effects, inferring the activity of disease-relevant regulators.
• Methods of clinical phenotype prediction from genome sequence.
• Models for longitudinal personal multi-omic data: high-dimensional time series analysis, disease onset prediction, finding genotype-dependent interactions between phenotypes and environment.
• Predictive models for disease, including biomarker selection and survival time prediction.
• Clinical applications of quantified self technology.
• Development of causal models for genotype, gene expression, disease labels and intermediate phenotypes.
• Improvement of existing methods to address the increasing demand for computational efficiency to allow for genome-scale applications.
• Methods of analysis for high temporal resolution physiological/phenotypic data.
• Comprehensive evaluation and comparison of existing methods in the context of practical applications.
• Innovative software for personalized medicine: for point-of-care use by physicians, analysis software for consumers and clinical geneticists, prioritisation and visualisation of genetic variation and longitudinal phenotypes for personalised biomedical data.

Other topics within the subject area are welcome.

Session Co-Chairs

Bruce Aronow Cincinnati Children's Hospital bruce.aronow@cchmc.org

Steven Brenner University of California, Berkeley brenner@compbio.berkeley.edu

Sean Mooney University of Washington sdmooney@uw.edu

Alexander Morgan Stanford University & Khosla Ventures alexmo@stanford.edu

Submission Information

 
Please note that the submitted papers are reviewed and accepted on a competitive basis.
 

Important Dates 

• Paper submissions due:July 27, 2015 August 13, 2015
• Notification of paper acceptance: September 14, 2015
• Camera-ready final paper deadline: October 5, 2015 at 23:59 PT

• Open for submissions for unreviewed poster abstracts: August 1, 2015
• Deadline for poster abstract submission: November 17, 2015 at noon PT

Paper Format

Please see the PSB paper format template and instructions at http://psb.stanford.edu/psb-online/psb-submit.

The file formats we accept are: postscript (*.ps) and Adobe Acrobat (*.pdf)). Attached files should be named with the last name of the first author (e.g. altman.ps or altman.pdf). Hardcopy submissions or unprocessed TeX or LaTeX files will be rejected without review.

Each paper must be accompanied by a cover letter. The cover letter must state the following:

• The email address of the corresponding author.
• The specific PSB session that should review the paper or abstract.
• The submitted paper contains original, unpublished results, and is not currently under consideration elsewhere.
• All co-authors concur with the contents of the paper.

Submitted papers are limited to twelve (12) pages in our publication format. Please format your paper according to instructions found at http://psb.stanford.edu/psb-online/psb-submit/. If figures cannot be easily resized and placed precisely in the text, then it should be clear that with appropriate modifications, the total manuscript length would be within the page limit.

Please note that, unlike many biology conferences, the PSB proceedings is an archival, peer-reviewed publication. PSB publications are indexed in MEDLINE/PubMed, and should be thought of as short journal articles.

Poster Format

Poster presenters will be provided with an easel and a poster board 32"W x 40"H (80x100cm). One poster from each paid participant is permitted.